TLR4 and type 2 diabetes mellitus: Results showed that the expression of TLR4 and MyD88 and the phosphorylation of IκB, and NF-κBp65 were significantly higher in the liver of rats in the T2DM group compared to those in the Control group, while the expression of all the above proteins was decreased after HD-BHRS treatment (Figures 4A, B).