For instance, mRNA expression of genes encoding astrocytic glutamate transporters (e.g., SLC1A2 and SLC1A3) and enzymes (e.g., glutamine synthetase) are reduced in the anterior cingulate cortex and dorsolateral prefrontal cortex of patients with MDD (Choudary et al., 2005). Here, SLC1A3 is linked to major depressive disorder.