To examine whether deletion of Htt exon 1 can alter gene expression, we performed RNA-seq analysis of the cortex, striatum, and cerebellum from three homozygous D177 and four WT mice at 6 months of age, as these three important brain regions show different vulnerability in HD (Ross and Tabrizi, 2011; Bates et al., 2015). The gene discussed is HTT; the disease is Huntington disease.