MAPK8 and myeloid sarcoma: The potential use of curcumin in the MS treatment was suggested by experiments showing that in lipo-polysaccharide-induced human astrocyte cell (U373-MG), the secretion of metalloproteinase (MMP)-9 involved in the enhancement of the BBB permeability, was reduced by curcumin (Eghbaliferiz et al., 2020), and that, in primary microglia of P3-P6 Sprague Dawley rats or C57BL/6 J mice, curcumin can control the axon degeneration, a final destructive stage in the pathogenesis of MS, reducing NO release, through the JNK phosphorylation pathway (Seyedzadeh et al., 2014; Tegenge et al., 2014).