GFAP and central nervous system cancer: In fact, the increased glial fibrillary acidic protein (GFAP) immunoreactivity, inhibition of replication/differentiation and induction of oxidative stress in C6 glioma cells, and of glial development in vivo, were reported (Garcia et al., 2001, 2002; Qiao et al., 2001; Zurich et al., 2004).