TRAF6 and neoplasm: Downregulation of Ube2o in alveolar macrophages (AMs) triggers TAK1- NF-κB/ERK/JNK signaling and CXCL10-induced CCL12 expression by inducing TRAF6 polyubiquitination and blocking DDX3X degradation in tumor environment, resulting in mo-MDSCs recruitment through the CXCL1-CXCR3/TLR4-CCL12 axis (62).