The number of polymorphonuclear MDSCs (PMN-MDSCs) are decreased in Alkbh5-KO tumors and MDSCs depletion attenuates tumor growth, which suggest that the regulation of immunosuppressive MDSCs recruitment via Alkbh5 is indispensable during GVAX/anti-PD-1 therapy. This evidence concerns the gene ALKBH5 and neoplasm.