Some studies have demonstrated that N6-methyladenylate (m6A) modification is involved in the progression of hepatitis B virus-related liver fibrosis by regulating the infiltration of immune cells (12), and at the same time, HBx carried by HBV can interact with the methylase METTL3, which is closely related to the development of HCC (13). The gene discussed is METTL3; the disease is hepatocellular carcinoma.