IL10 and neoplasm: TAMs are crucial drivers of immunosuppression in the TME: mediators released by tumor cells and infiltrating lymphocytes, like Th2 cells and Treg cells, and activate an immunosuppressive profile in TAMs (30, 31): as a consequence, immunosuppressive TAMs show a secretory profile characterized by low levels of cytokines promoting adaptive immune responses, as IL-12, IL-18, and high levels of anti-inflammatory/proresolving cytokines such as IL-10 and TGF-β (32).