On the one hand, by increasing NAD metabolism to promote the proliferation of B cells naïve population, On the other hand, with the gradual proliferation of the B cell naïve population, it released certain negative feedback regulators, this resulted in the inhibition of SIRT3 and NADSYN1 expression, and the negative feedback effect was stronger than the effect of some tumor factors. Here, NADSYN1 is linked to neoplasm.