FOXP3 and tongue cancer: Although the high density of Foxp3 positive TILs was consistently associated with poor survival in patients with operable tongue cancer (37), breast cancer (38), hepatocellular cancer (39), ovarian cancer (40), and esophageal cancer (41), it was also reported to be associated with favorable outcomes in patients with head and neck squamous cell cancer (42), colorectal cancer (43), and SCLC (44).