MMP3 and rheumatoid arthritis: found that the ethyl acetate fraction from Angelica sinensis (EAAS) could suppress the expression of COX-2, MMP-1 and MMP-3, decrease PGE2 production, and inhibit the activation of NF-κB and phosphorylation of MAPK pathways in IL-1β-induced RASFs, suggesting that EAAS treated RA via anti-inflammation effects (83).