ITGAM and head and neck squamous cell carcinoma: To better characterize regulatory aspects of myeloid inflammasome signaling within the tumor, we initially performed bulk RNA sequencing of CD11b+ myeloid cells sorted from human head & neck squamous cell carcinoma (HNSCC) tumors with matched peripheral blood mononuclear cells (PBMC) (Figure 3A, Supplementary Figures S1A–C).