Efferocytosis of tumor AC downregulated several well-known inflammatory genes like nos2, il18, ccl5, cd40, cxcl10, cxcl11, cgas, ifnlr1 and Il12rb1 and increased the expression of multiple immune suppressive and tumor-promoting genes like tgfbi, arg2, mmp19, cd276, cxcl1, cxcl14, cxcl3, cxcl2 and vegfa (Figure 7A, Supplementary Tables S7) (61). This evidence concerns the gene NOS2 and neoplasm.