C1QC and cancer: We identified 8 broadly defined tumor-infiltrating CD45+ immune cell subsets (Figures 4A, B) including LILRA4+ plasmacytoid dendritic cells (pDC), C1QC+ and LYZ+ myeloid cells encompassing monocytes, macrophages and conventional dendritic cells (MoMacDC; mononuclear phagocytes), CD3+ T cells, KLRC1+ NK cells, MS4A1+ (CD20) B cells, IGHA1+ plasma cells, KIT+ mast cells, and OSM+ neutrophils, broadly consistent with recent sc-RNA seq studies from multiple cancer types (41, 42, 60–68).