ISG15 and neoplasm: Our analysis revealed 5 tumor-infiltrating macrophage subsets - Macro_C1QC (FCGR3A/C1QC/C1QA), Macro_INHBA (INHBA/CXCL8/CCL4), Macro_ISG15 (TYMP/ISG15/IFITM3), Macro_NLRP3 (NLRP3/IL1B/BCL2A1) and Macro_SPP1 (SPP1/APOC1/CSTB) - and 3 monocyte subsets (Mono_CD14, Mono_CD16, and Mono_CD14CD16) along with 4 tumor-infiltrating DC subsets (cDC1_CLEC9A, cDC2_CD1c, cDC3_LAMP3 and pDC_LILRA4) and mast cells (Figures 4C, D).