Additionally, IPA and GO analyses showed efferocytic macrophages enriched and upregulated several tumor supportive pathways including IL-10 signaling, T cell exhaustion pathway, and PD-1/PD-L1 signaling pathways which were also enriched in our human tumor derived myeloid cell transcriptomic profiles (Figures 3C, 6B) (89, 90). This evidence concerns the gene IL10 and neoplasm.