While some GI and colon tumor models indicate that tumor-intrinsic inflammasome signaling may have anti-tumorigenic effects (103, 104), we have complemented our in vivo studies with a single cell transcriptomic profile of human squamous carcinoma that corroborates a distinct pro-tumorigenic role for the myeloid-intrinsic NLRP3-dependent inflammasome. The gene discussed is NLRP3; the disease is colonic neoplasm.