Human ovarian cancer cell lines OVCAR3, A2780, A2780/DDP and A2780/Taxol were exposed to paclitaxel or cisplatin transfected with or without miR-186, and miR-186 was found to induce sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1. The gene discussed is ABCB1; the disease is ovarian cancer.