IL6 and COVID-19: Similarly, LD1 in pDCs showed that the vS group is more enriched with cell cycle-related signature such as G2M checkpoint and E2F targets; in contrast, in LD2, transciptional signatures of pDCs from COVID-19 patients were enriched with inflammatory response, IL6 signaling and, interferon-gamma responses, consistent with other studies (26, 37) (Figures 3C, D).