Based on the results from Peiris et al. (47) and Bastaki et al. (43), menthol-related TRPM8 may be a potential anti-inflammatory mediator in irritable bowel syndrome patients for the increased TRPM8-IR on dendritic cells within the colonic mucosa coupled with decreased release of cytokines, which delineate the potential cellular mechanisms underlying the therapeutic benefit of menthol. Here, TRPM8 is linked to irritable bowel syndrome.