Additionally, decreased release of IP-10 and TNF-α after ex vivo blood stimulation with endotoxin was associated with poor outcomes after stroke, suggesting that the inhibition of both the MyD88-dependent and MyD88-independent pathways of toll-like receptors (TLR)4 signaling in blood cells was associated with poor prognosis in stroke patients (87). This evidence concerns the gene TLR4 and stroke disorder.