PLIN2 and acne: PPARγ and its target genes adipose differentiation-related protein gene (ADRP), encoding adipophilin, and angiopoietin-related gene (PGAR), which regulates lipogenic pathways and sebaceous lipogenesis at protein and mRNA level, are expressed at lower levels in SG in both involved and non-involved skin from acne patients associated with the increase in endogenous lipid ligands, such as eicosanoids.