Previous studies showed that important inflammatory molecules, such as IL6, IL8, TNFα, 5-lipoxygenase (5LOX) or cyclooxygenase 2 [COX2; a.k.a. prostaglandin-endoperoxide synthase (PTGS2)] are increased in lesional sebocytes of acne patients (97, 109). The gene discussed is TNF; the disease is acne.