In 1993, Napoleone Ferrara’s group uncovered a remarkable decrease in microvascular density and dramatic retardation of tumor growth in the nude mice harboring xenografts of glioblastoma multiforme, rhabdomyosarcoma and leiomyosarcoma following the treatment of an effective anti-VEGF monoclonal antibody (134). This evidence concerns the gene VEGFA and glioblastoma.