Despite that neutrophils are featured with an eventually differentiated phenotype with short half-life property, these cells are still able to harbor a certain type of plasticity that enables them to differentiate into two different subpopulations: type 1 neutrophils (N1) with anti-microbial function, and TANs or N2 neutrophils with conspicuous pro-tumor and pro-angiogenic characteristics in the presence of TGF-β (87). The gene discussed is TGFB1; the disease is neoplasm.