Indeed, it has also been documented that B lymphocytes are capable of potently strengthening tumor angiogenesis via promoting the secretion of an array of critical pro-angiogenic factors including VEGF, FGF-2, and MMP-9 (127), or indirectly via skewing the polarization of TAMs towards an pro-angiogenic and immunosuppressive M2-phenotypic TAMs in an IgG-dependent manner (128). This evidence concerns the gene MMP9 and neoplasm.