In the both CD4−/− and CD8−/− mouse tumor models, it was shown that suppression of CTLA-4 and PD-1 was able to induce tumor vascular normalization through activating the Th1 cells. Nonetheless, it was deciphered that CD4+ T cells alone failed to sufficiently give rise to the remodeling of tumor blood vessels (180). Here, CTLA4 is linked to neoplasm.