Based on our prior studies in our 2-hit burn wound infection model whereby MPLA mediated enhanced leukocyte responses to infection induced after severe burn injury (11), it is postulated that induction of trained immunity by MyD88-activation has the potential to augment leukocyte function after trauma and restore immunocompetence in this model, a question that is currently being pursued by our group. Here, MYD88 is linked to infection.