Here, superficial vessel loss has been shown to be a consistent finding in patients with relapsing remitting multiple sclerosis and a history of ON (7, 8, 20, 21) and we could recently show, that rarefication of the SVC but not the DVC occurs within the first three months after acute ON and evolves simultaneously to GCIP atrophy (6). Here, CCNDBP1 is linked to relapsing-remitting multiple sclerosis.