IL2RG and neoplasm: IL-15 is a potent stimulator of CD8+ T cells and NK cells via the activation of IL-15Rα, IL-2Rβ (also named CD122), and IL-2Rγ (also named CD132), which share receptors with IL-2, IL-4, IL-7, IL-9, and IL-21, and thereby reduces tumor burden (10, 11).