TBC1D12 and basal cell carcinoma: RPN2 is involved in the following signaling pathway: Basal cell carcinoma, complement and coagulation cascades, DNA replication, and protein export (Figure 8F); The main signaling pathways impacted by TBC1D12 include beta-alanine metabolism, the complement and coagulation cascades, the H coagulation cascades and histidine metabolism (Figure 8G).