MBNL2 belongs to a family of highly conserved RNA-binding proteins that drive cancer cell proliferation and migration by regulating the expression of hypoxia-inducible genes, such as VEGF-A, and variable splicing (54); MBNL2 expression levels were significantly negatively correlated with hepatocellular carcinoma tumor size and stage, and MBNL2 overexpression in vitro and in vivo inhibited the growth and invasion of hepatocellular carcinoma cells (55); MBNL2 also regulates tumor cell proliferation and the DNA damage response by stabilizing p21 (56). This evidence concerns the gene VEGFA and hepatocellular carcinoma.