A comparison of trAEs between PD-1 and PD-L1 inhibitors combined with TRT is shown in Table 3. A pooled subgroup analysis was not possible for RCCEP, leukopenia, lymphopenia, and anemia, because clinical trials reporting these trAEs all just used PD-1 inhibitors alone, except for high-grade leukopenia. This evidence concerns the gene PDCD1 and anemia (phenotype).