Factors contributing to the poor immunogenicity of these so-called “cold tumors” include inadequate tumor-associated antigen uptake and impaired cross-priming capability of antigen-presenting cells in the tumor microenvironment, which, in turn, fosters insufficient production of antigen-specific CD8 T cells, functional incompetence of T effectors, and unsustainable antitumor immune memory (2). Here, CD8A is linked to neoplasm.