In early reports of IgG4 isotypes of anti-CD47 mAb, treatment-related anemia for AK117 (16), TJC4 (28), and IBI188 (26) were 40%, 40%, and 15% for grade 1-2 and 0%, 0%, and 5% for grade 3, respectively. The gene discussed is CD47; the disease is anemia (phenotype).