Treatment of IFNAR2WT iPS-Mφ with RUX for 16 h prior to infection led to a significant enhancement of ZIKV-induced cell death compared to vehicle (DMSO) treatment (Figure 6), reproducing our previous observations in IFNAR2PT iPS-Mφ and suggesting that loss of the inducible signalling response to ZIKV infection is the major mechanism by which IFNAR2 deficiency contributes to macrophage susceptibility. The gene discussed is IFNAR2; the disease is infection.