To address the impact of IFN-I signalling on macrophage responses to ZIKV infection, we derived induced pluripotent stem cells (iPSC) from dermal fibroblasts from a patient bearing a homozygous nonsense mutation of IFNAR2 (26), the high-affinity subunit of the IFN-I receptor (herein termed IFNAR2PT). This evidence concerns the gene IFNAR2 and Zika virus infectious disease.