In the co-seasonal ASIT regimen, the correlation of total IgE with signs of allergic rhinitis (r=0.7-0.84, P=0.015 - P<0.0001) and bronchial asthma (r=0.7-0.79, P=0.01 - P<0.0001) became even more pronounced. The gene discussed is IGHE; the disease is allergic rhinitis.