TNF and neoplasm: Natural products also have significant actions on tumor immunosuppressive factors and cells, promoting the secretion of anti-tumor immune factors (IL-1βI, TNF-α, FN-γ), inhibiting the secretion of immunosuppressive factors (TGF-β, IL-10, PGE2), down-regulating the number of immunosuppressive cells (MDSC, Tregs, M1 macrophages) and enhancing the TEFF activity and quantity (112).