MAP3K5 and non-small cell lung carcinoma: Moreover, berberine triggers apoptosis-related responses such as cleavage of caspase-3, release of cytochrome c and depolarization of the mitochondrial membrane in non-small cell lung cancer through activation of apoptosis signal-regulated kinase 1 (ASK1) and c-jun NH2 kinase (JNK) via the ROS pathway (84).