The inflammatory microenvironment is an essential component of the tumor microenvironment, where cytokines such as VEGF-A and CCL2/MCP-1 induce angiogenesis with the recruitment of monocytes and neutrophils into the tumor niche to transform into tumor-associated monocyte-macrophages (TAM) and tumor-associated neutrophils (TAN) (103, 104). The gene discussed is CCL2; the disease is neoplasm.