CD274 and cancer: In TCGA and GEO cohorts, there was no clear evidence for a positive association between PD-L1 mRNA and CFR (Spearman’s correlation test; TCGA: r = −0.13, 95% CI, −0.19 to −0.07, p = 0.001; GEO: r = −0.11, 95% CI, −0.18 to −0.02, p = 0.008), as was further confirmed in IMvigor210, PRJEB23709, and most cohorts in pan-cancer (Figure 4D).