The correlation analysis between the antibody concentration after COVID-19 vaccine injection and the thickness of each layer in the macular region was performed on 90 patients (90 eyes) in the antibody group (IgM group + IgG group), 12 patients (12 eyes) in IgM group, and 78 patients (78 eyes) in the IgG group. This evidence concerns the gene CD40LG and COVID-19.