The ECM comprises the majority of non-cellular TME, such as laminin, collagen, and fibronectin, while the cellular components surrounding tumor cells include immune cells (such as lymphocytes, NK cells, macrophages and dendritic cells) and non-immune cells (such as fibroblasts and vascular endothelial cells), collectively determining their roles in tumorigenesis and tumor progression. The gene discussed is LAMB2; the disease is neoplasm.