For example, transcriptomic analysis through Illumina RNA-Seq on total brain, frontal and temporal lobes of healthy and AD post-mortem tissue revealed an overrepresentation of neuron's cytological structure and synapse function-related genes in AD brain, and alternative splicing and promoter of the APOE gene in AD brain is correlated with the progression of neurodegeneration 37. This evidence concerns the gene APOE and Alzheimer disease.