As evident in Figs 3B and 3C, PCBP2, FTL, and SLC7A11 were significantly up-regulated in AD, while VDAC2, LPCAT3, GSS, ACSL4, ACSL6, and ATG7 were down-regulated, indicating that ferroptosis was altered in AD hippocampus. The gene discussed is ACSL4; the disease is Alzheimer disease.