AKT1 and lung cancer: It also exerts inhibitory effects in human lung cancer A549 cells (IC50 values were 31.88, 14.53, and 5.04 μM at 24, 48, and 72 h) and mediates apoptosis and autophagy through the regulation the PI3K/Akt signaling pathway, generation of reactive oxygen species, and loss of mitochondrial transmembrane potential 29.