AKT1 and cancer: In addition, cedrol activates intrinsic apoptosis, suppresses the AKT/ERK/mTOR and NF-κB signaling pathways, and chemosensitizes cancer cells through lipid raft destabilization in human leukemia K562 and colon cancer HT-29 cells, with an IC50 of 179.52 and 185.50 μM at 48 h, respectively 32.