Gai et al. 56 found that carboxymethylated pachyman (a carboxymethylated derivative of pachyman derived from Poria cocos) can induce ferroptosis by downregulating Nrf2 mRNA, and reducing Nrf2, HO-1, GPX4 protein levels in ovarian cancer cells. The gene discussed is NFE2L2; the disease is ovarian carcinoma.