Toshiro Moroishi et al. established three different mouse homologous tumor models (B16, SCC7 and 4T1), which confirmed that the lack of Hippo pathway kinase LATS1/2 (large tumor suppressor 1 and 2) in tumor cells could improve tumor immunogenicity, thereby enhancing anti-tumor immune response and inhibit tumor growth 46. The gene discussed is LATS1; the disease is neoplasm.