The lncRNA ncRuPAR (non-protein coding RNA, upstream of coagulation factor II thrombin receptor [F2R]/protease-activated receptor-1 [PAR-1]) located on chromosome 5 has been shown to regulate gastric cancer malignancy, wherein its downregulation can promote angiogenesis, invasion, metastasis and progression 7,12. The gene discussed is F2R; the disease is gastric cancer.