In the training set, a higher level of red cell distribution width (RDW), blood urea nitrogen (BUN), uric acid (UA), osmolality, parathyroid hormone (PTH), C-peptide, homocysteine (HCY), retinol, methylmalonic acid (MMA) and urine albumin were associated with increased risk of CKD. The gene discussed is PTH; the disease is chronic kidney disease.