In this regard, analyzing the activity of enzymes-related to ATP production and as compared to HPMEC incubated with LPS alone, COVID-19 spike S1+S2 subunits promoted on LPS-incubated HPMEC the following changes: 1.- Reduction of ΔΨm; 2.- Enhancement of cytochrome c oxidase activity; 3.- Enhancement of LDH activity without changes in LDH expression; 4.-Increased expression of mitochondrial UCP-2 protein. The gene discussed is UCP2; the disease is COVID-19.