NFKB1 and neoplasm: It has been reported that nuclear transcription factor- (NF-) κB consists of five subunits, including NF-κB p65, and that NF-κBp65 is activated in response to pathogenic factors, while tumor tissue T cells are activated to secrete large amounts of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α, all of which have immunosuppressive effects and are thus involved in the immune escape of malignant tumor cells [20].