This suggests that TREM2 plays a pro-proliferative role in thyroid cancer cells by activating the NF-κB signaling pathway and upregulating the expression of cyclin D1 and Bcl2; after blocking the expression of NF-κB protein using different concentrations of the small molecule inhibitor pyrrolidine dithiocarbamate (PDTC) (25-100 μM), the expression of p-NF-κBp65 and p-IκB-α protein was significantly downregulated as the PDTC dose gradually increased. The gene discussed is NFKBIA; the disease is thyroid cancer.