Research shows that, during epilepsy (incubation period), the levels of total gephyrin and GABAAR subunits γ2, α2/3, and α4 protein in the hippocampus of animals decreased significantly, and gephyrin knockout mice died in a state similar to status epilepticus within 24 h of birth (Groeneweg et al., 2018). This evidence concerns the gene GPHN and epilepsy.