Our results are consistent with previous reports of the EP4 receptor playing a key role in a variety of disease models associated with increased inflammation, including type 1 diabetes (Rahman et al., 2018), endometritis (Li et al., 2019), angiotensin II-induced abdominal aortic aneurysm (Hiromi et al., 2020), airway inflammation (van Geffen et al., 2021), and nephrotoxic serum nephritis (Aringer et al., 2018). This evidence concerns the gene AGT and abdominal aortic aneurysm.