The results of our previous study showed that mPGES-1 promoted the synthesis of extracellular matrix protein via activation of the NLRP3 inflammasome in RPMCs exposed to high levels of glucose (Luo et al., 2021), indicating that the NLRP3 inflammasome participated in peritoneal fibrosis. This evidence concerns the gene NLRP3 and Peritoneal Fibrosis.