Some Bifidobacterium spp. cause the reduction of proinflammatory factor IL-6 (Table 1) (Figure 1) and the high accumulation of mature DCs, helper T cells (Th), and cytotoxic T cells (CTLs) at tumor sites under IL-6-deficient conditions (Table 1) (Singh, et al., 2020; Chen, et al., 2021c; Cui, et al., 2022). Here, IL6 is linked to neoplasm.