AKT1 and gastric cancer: Baicalein reduces the levels of HIF-1α in AGS gastric cancer cells in a dose-dependent manner (10, 20, and 40 μM); down-regulates the levels of HK2, LDHA, and PDK1; inhibits Akt phosphorylation under hypoxic conditions; promotes the expression of PTEN protein, and gradually restores glucose uptake and lactic acid production in hypoxic AGS cells to those observed under normoxic conditions (Chen et al., 2015).