Baicalein reduces the levels of HIF-1α in AGS gastric cancer cells in a dose-dependent manner (10, 20, and 40 μM); down-regulates the levels of HK2, LDHA, and PDK1; inhibits Akt phosphorylation under hypoxic conditions; promotes the expression of PTEN protein, and gradually restores glucose uptake and lactic acid production in hypoxic AGS cells to those observed under normoxic conditions (Chen et al., 2015). Here, HK2 is linked to gastric cancer.