AKT phosphorylation up-regulates the expressions of GLUTs and HK2, improves the activity of glycolysis and mammalian targets of the rapamycin (mTOR) (Courtney et al., 2010), and stimulates glycolysis by inducing the expression of HF1-α, a major signaling pathway involved in the regulation of aerobic glycolysis and tumor growth (Rosen and She, 2006; Xie et al., 2019). Here, HK2 is linked to neoplasm.