Following the absorptions of glucose, hexokinase (HK) catalyzes the process of glucose phosphorylation to produce glucose 6-phosphate (G6P), which is then catalyzed by phosphofructokinase-1 (PFK-1), pyruvate kinase (PK), lactate dehydrogenase (LDH), and other enzymes, to generate energy and various metabolic substrates that can be used for the synthesis of lipids, amino acids, and other substances in tumor cells (Hatzivassiliou et al., 2005; Vander Heiden et al., 2009; Lunt and Vander Heiden, 2011; Huang et al., 2014). This evidence concerns the gene PFKM and neoplasm.