In vitro experiments have confirmed that CGs reduce the levels of GLUT1 in MKN45 cells, and induce dynamin-dependent GLUT1 endocytosis, resulting in subsequent GLUT1 degradation in lysosomes, which significantly affects the uptake of glucose by cancer cells, thereby inhibiting glycolysis in gastric cancer cells (Fujii et al., 2022). This evidence concerns the gene SLC2A1 and gastric cancer.