WZ35 can increase the levels of ROS and c-Jun N-terminal kinase (JNK), while decrease the expression of Yes-associated protein (YAP) in patients with gastric cancer, indicating that WZ35 may inhibit glycolysis by activating ROS, resulting in the regulation of the YAP-JNK pathway (Chen T. et al., 2020). This evidence concerns the gene MAPK8 and gastric cancer.