On the subject of anti-inflammation potential of piperin, Roshanbakhsh et al. (2020) observed the depletion of pro-inflammatory mediators such as TNF-α, IL-1β, and NF-κB signaling pathway, iNOS expression, and glial activation in the hippocampus of AD animal models treated with piperin (5, 10, 20 mg/kg–every day for 10 days). The gene discussed is NFKB1; the disease is Alzheimer disease.