Soleimannejad et al. (2017) showed that black cumin seed extract improved global ischemia outcomes at doses of 10 and 20 mg/kg through an angiogenic process involving up-regulating vascular endothelial growth factor (VEGF) gene expression, matrix metallopeptidase (MMP9), and hypoxia-inducible factor-1 (HIF). The gene discussed is VEGFA; the disease is ischemia.