Prema et al. (2017) reported that this AChE inhibitory activity is associated with FSE-mediated activation of the Akt/GSK3β pathway, which also led to ameliorated memory and learning difficulties, Al toxicity, AChE hyperactivity, amyloid β (Aβ) aggregation, and apoptosis, in rats with AD-like AlCl3–induced memory loss in this study. Here, ACHE is linked to Alzheimer disease.