Data from tissues of children that suffer from the inflammatory lung disease cystic fibrosis suggest that decreased expression of ALOX15B is associated with low LXA4 levels (Ringholz et al., 2014) and that the activity of TLR4, which binds LPS, is crucial to maintain tissue homeostasis and to promote resolution of inflammation (Yang et al., 2012). The gene discussed is ALOX15B; the disease is cystic fibrosis.