Furthermore, cells with F508del CFTR [a phenylalanine deletion common in cystic fibrosis patients (Nieddu et al., 2013)] demonstrated a further reduction of ALOX15B expression when compared to the WT CFTR expression in CFBE41o− bronchial epithelial cells (Shum et al., 2022). This evidence concerns the gene ALOX15B and cystic fibrosis.