While normal prostate epithelium expresses ALOX15B but not ALOX15 in the luminal compartment (Subbarayan et al., 2006), expression of ALOX15B was lost in prostate cancer (Shappell et al., 1999; Bhatia et al., 2005) as well as associated cell lines (Tang et al., 2002), and also 15-HETE production was found to be reduced (Shappell et al., 2001b). The gene discussed is ALOX15; the disease is Familial prostate cancer.