Treatment of normal human epidermal keratinocytes and the keratinocyte cell line HaCaT with interferon-γ (IFNγ) (Setsu et al., 2006) or tumor necrosis factor-α (TNFα) in normal human epidermal keratinocytes (Banno et al., 2004) induced ALOX15B expression, indicating immune cell infiltration and inflammation may both induce epidermal ALOX15B in inflammatory skin diseases along with macrophage ALOX15B expression aiding in the production of oxylipins. Here, TNF is linked to inflammatory skin disease.