Whereas in prostate (Shappell et al., 1999; Bhatia et al., 2003; Tang et al., 2004; Suraneni et al., 2010) and breast carcinoma (Kort et al., 1992; Jiang et al., 2006; Vaezi et al., 2021; Wu et al., 2021) ALOX15B is downregulated, expression of ALOX15B in colorectal cancer is associated with a poorer prognosis (Yuan et al., 2020). The gene discussed is ALOX15B; the disease is colorectal cancer.