Table 3 provides further insight into expression alterations of ALOX15B or its products 15-HETE and 13-HODE in different types of cancers. Moreover, research towards ALOX15B silencing or overexpression in cancer cells lines has been performed, providing further insight. The data suggest a role of ALOX15B in cellular signaling pathways (PPAR, MAPK/ERK, AKT), which are linked to cellular survival, proliferation, and apoptosis (Figure 6). This evidence concerns the gene AKT1 and cancer.