ALOX15B and prostate carcinoma: While the ALOX15B corresponding murine ortholog Alox8 is not expressed in murine prostate glands (Shappell et al., 2003), humanized ALOX15B overexpression studies have been performed in vivo. Prostate carcinoma PC3 cells (which do not express ALOX15B) were injected into the mouse prostate to develop tumors and stable ALOX15B overexpression resulted in significantly smaller tumors (Bhatia et al., 2003).