ALOX15B and Familial prostate cancer: Whereas treatment of breast cancer cell lines with dihydroxytestosterone (DHT) upregulated ALOX15B expression (Vasiliou et al., 2022), treatment of prostate cancer with DHT did not induce ALOX15B expression, although a partially matched androgen response element (ARE) was described to be located within ∼1.4 kb upstream of the ALOX15B transcription start site (Tang et al., 2004).