Their an mechanisim may be that they can promote the proliferation of T lymphocytes, secrete the cytokine interleukin-2, inhibits the secretion of interleukin-8, downregulates the protein expression of VEGF and MMP-9, restrain the formation of new blood vessels, and control tumor cell adhesion (Tao et al., 2017; Wen et al., 2013; Wu et al., 2021). Here, VEGFA is linked to neoplasm.