Furthermore, the alteration incidence of epidermal growth factor receptor (EGFR), which was recognized as essential for glioma development and frequently mutated, amplified, and overexpressed in malignant glioma (Eskilsson et al., 2018), was significantly different in two subgroups, suggesting potential interactions between purine metabolism and EGFR. The gene discussed is EGFR; the disease is malignant glioma.