For instance, METTL3 and METTL14, as methylating enzymes, regulate a variety of malignant events, including tumor proliferation, metastasis, stemness maintenance, and chemotherapy resistance (Li et al., 2019; Wang et al., 2020b; Xu et al., 2021; Zhang et al., 2021). The gene discussed is METTL3; the disease is neoplasm.