It is possible to induce NASH-like liver pathology using diets that are deficient in choline, or methionine choline or contain high amounts of fat and cholesterol; this would result in the elevated expression levels of CD1d, accumulation of intrahepatic iNKT cells and consequently, enhanced fibrinogenesis, higher levels of alanine aminotransferase (ALT) and increased NASH disease scores (Syn et al., 2010; Syn et al., 2012; Wolf et al., 2014; Bhattacharjee et al., 2017). This evidence concerns the gene CD1D and metabolic dysfunction-associated steatohepatitis.