Moreover, increasing abdominal fat mass is associated with insulin resistance as one inflammation indicator (14) and ablation of Galectin-3 (Gal-3), which hastens lipid-induced atherogenesis and plays an essential role in cell-cell adhesion, cell-matrix interactions, macrophage activation, metastasis, and apoptosis (15, 16). The gene discussed is LGALS3; the disease is Insulin resistance.