These included rs2943656 in/near IRS1, rs9991501 in/near HSD17B11, rs2287926 in/near VCAN, rs4842924 in/near ADAMTSL3, and rs9936385 in/near FTO which are all available in NAFLD GWAS (Table 1). This evidence concerns the gene IRS1 and metabolic dysfunction-associated steatotic liver disease.