VEGF is a provascular endothelial growth factor induced by hypoxia, which can increase vascular permeability by binding to vascular endothelial cell receptors, induce endothelial cell proliferation as well as promote stromal lysis and inflammatory exudation, and accelerate the proliferation of tumor cells, therefore, the proliferation and differentiation of tumor cells can be reduced by inhibiting the expression of VEGF, which facilitates clinical treatment [23]. The gene discussed is VEGFA; the disease is neoplasm.